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Article

Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling.

Cell cycle (Georgetown, Tex.) - 15 Jun 2009

De La O Jean-Paul, Murtaugh L Charles

Abstract excerpt

Activating mutations in the KRAS proto-oncogene occur almost ubiquitously in pancreatic ductal adenocarcinoma (PDAC) and in its putative precursor lesions, pancreatic intraepithelial neoplasia (PanIN). Conditional expression of an activated Kras allele in the mouse pancreas produces a model that faithfully recapitulates PanIN formation and progression to PDAC. Importantly, although nearly every cell in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19440048
DOI: 10.4161/cc.8.12.8744
PMCID: PMC2719432

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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