Article
TGF-beta signalling in colon carcinogenesis.
Cancer letters - 1 Jan 2012
Lampropoulos Pavlos, Zizi-Sermpetzoglou Adamantia, Rizos Spyros, Kostakis Alkiviadis, Nikiteas Nikolaos, Papavassiliou Athanasios G
Abstract excerpt
Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway. The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-β...
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