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Article

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.

Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2017

Silverman Michael, Kua Lindsay, Tanca Alessandro, Pala Mauro, Palomba Antonio, Tanes Ceylan, Bittinger Kyle, Uzzau Sergio, Benoist Christophe, Mathis Diane

Abstract excerpt

Certain MHC-II or HLA-D alleles dominantly protect from particular autoimmune diseases. For example, expression of the MHC-II Eα:Eβ complex potently protects nonobese diabetic (NOD) mice, which normally lack this isotype, from spontaneous development of type 1 diabetes. However, the underlying mechanisms remain debated. We investigated MHC-II-mediated protection from type 1 diabetes using a previously reported...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28831005
DOI: 10.1073/pnas.1712280114
PMCID: PMC5594701

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