Article
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
Development (Cambridge, England) - 1 Mar 2009
Matthews Randolph P, Lorent Kristin, Mañoral-Mobias Rafael, Huang Yuehua, Gong Weilong, Murray Ian V J, Blair Ian A, Pack Michael
Abstract excerpt
Hepatic steatosis and liver degeneration are prominent features of the zebrafish ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy). Reduced Ahcy activity in dtp mutants led to elevated levels of S-adenosylhomocysteine (SAH) and, to a lesser degree, of its metabolic precursor S-adenosylmethionine (SAM). Elevated SAH in...
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