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Article

Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.

Cell reports - 8 May 2014

Obata Fumiaki, Kuranaga Erina, Tomioka Katsura, Ming Ming, Takeishi Asuka, Chen Chun-Hong, Soga Tomoyoshi, Miura Masayuki

Abstract excerpt

Sterile inflammation triggered by endogenous factors is thought to contribute to the pathogenesis of acute and chronic inflammatory diseases. Here, we demonstrate that apoptosis-deficient mutants spontaneously develop a necrosis-driven systemic immune response in Drosophila and provide an in vivo model for studying the organismal response to sterile inflammation. Metabolomic analysis of hemolymph from...

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Source

Identifiers

PMID: 24746817
DOI: 10.1016/j.celrep.2014.03.046

Genes

GNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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