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Article

The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model.

Disease models & mechanisms - 1 Jan 2000

Curado Silvia, Ober Elke A, Walsh Susan, Cortes-Hernandez Paulina, Verkade Heather, Koehler Carla M, Stainier Didier Y R

Abstract excerpt

Understanding liver development should lead to greater insights into liver diseases and improve therapeutic strategies. In a forward genetic screen for genes regulating liver development in zebrafish, we identified a mutant--oliver--that exhibits liver-specific defects. In oliver mutants, the liver is specified, bile ducts form and hepatocytes differentiate. However, the hepatocytes die shortly after their...

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Source

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Identifiers

PMID: 20483998
DOI: 10.1242/dmm.004390
PMCID: PMC2898538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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