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Article

Dietary Shift Leads to Venous Thrombosis-Induced Congestive Liver Failure in CBS-Deficient Mice.

Journal of inherited metabolic disease - 1 Sept 2025

Lee Hyung-Ok, Qai Cathy Q, Slifker Michael J, Kruger Warren D

Abstract excerpt

Cystathionine beta-synthase (CBS) deficiency is an inborn error of metabolism that results in a large increase in plasma total homocysteine (tHcy) and a significant risk of venous thrombosis. Although a mouse model of CBS deficiency (Tg-I278T Cbs-/-) has several phenotypes in common with human patients, it has not been shown to have elevated thrombosis risk. Here, we describe a novel phenotype in which 40% of...

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Identifiers

PMID: 40765259
DOI: 10.1002/jimd.70076
PMCID: PMC12969802

Genes

CBS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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