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Article

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

The American journal of clinical nutrition - 1 Mar 2015

Christensen Karen E, Mikael Leonie G, Leung Kit-Yi, Lévesque Nancy, Deng Liyuan, Wu Qing, Malysheva Olga V, Best Ana, Caudill Marie A, Greene Nicholas D E, Rozen Rima

Abstract excerpt

BACKGROUND: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. OBJECTIVE: Our goal was to investigate the impact of high folic acid...

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Identifiers

PMID: 25733650
DOI: 10.3945/ajcn.114.086603
PMCID: PMC4340065

Genes

MTHFR

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