Article
Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis.
Hepatology (Baltimore, Md.) - 1 Oct 2013
Nussbaum Justin M, Liu Liuhong J, Hasan Syeda A, Schaub Madeline, McClendon Allyson, Stainier Didier Y R, Sakaguchi Takuya F
Abstract excerpt
UNLABELLED: Nonalcoholic fatty liver disease is the most common liver disease in both adults and children. The earliest stage of this disease is hepatic steatosis, in which triglycerides are deposited as cytoplasmic lipid droplets in hepatocytes. Through a forward genetic approach in zebrafish, we found that guanosine monophosphate (GMP) synthetase mutant larvae develop hepatic steatosis. We further demonstrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.