Article
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
Gut - 1 Jun 2009
Festen E A M, Goyette P, Scott R, Annese V, Zhernakova A, Lian J, Lefèbvre C, Brant S R, Cho J H, Silverberg M S, Taylor K D, de Jong D J, Stokkers P C, Mcgovern D, Palmieri O, Achkar J-P, Xavier R J, Daly M J, Duerr R H, Wijmenga C, Weersma R K, Rioux J D
Abstract excerpt
OBJECTIVES: Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn's disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac dise...
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