Article
Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.
Genes and immunity - 1 Jun 2008
Adamovic S, Amundsen S S, Lie B A, Gudjónsdóttir A H, Ascher H, Ek J, van Heel D A, Nilsson S, Sollid L M, Torinsson Naluai A
Abstract excerpt
The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in FcgammaRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide...
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