Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

doi:10.1038/ng.203

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Article

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

Nature genetics - 1 Oct 2008

Kugathasan Subra, Baldassano Robert N, Bradfield Jonathan P, Sleiman Patrick M A, Imielinski Marcin, Guthery Stephen L, Cucchiara Salvatore, Kim Cecilia E, Frackelton Edward C, Annaiah Kiran, Glessner Joseph T, Santa Erin, Willson Tara, Eckert Andrew W, Bonkowski Erin, Shaner Julie L, Smith Ryan M, Otieno F George, Peterson Nicholas, Abrams Debra J, Chiavacci Rosetta M, Grundmeier Robert, Mamula Petar, Tomer Gitit, Piccoli David A, Monos Dimitri S, Annese Vito, Denson Lee A, Grant Struan F A, Hakonarson Hakon

Abstract excerpt

Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal barrier and persistent dysregulation of the immune response to commensal intestinal bacteria. IBD is characterized by two distinct phenotypes: Crohn's disease (CD) and ulcerative colitis (UC)....

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PMID: 18758464
DOI: 10.1038/ng.203
PMCID: PMC2770437

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PSMG1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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