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Article

A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals.

American journal of human genetics - 1 Feb 2009

Browning Brian L, Browning Sharon R

Abstract excerpt

We present methods for imputing data for ungenotyped markers and for inferring haplotype phase in large data sets of unrelated individuals and parent-offspring trios. Our methods make use of known haplotype phase when it is available, and our methods are computationally efficient so that the full information in large reference panels with thousands of individuals is utilized. We demonstrate that substantial gains...

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Identifiers

PMID: 19200528
DOI: 10.1016/j.ajhg.2009.01.005
PMCID: PMC2668004

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Source receipt: pubmed, retrieved 7 Sept 2026.

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