Article
High-accuracy haplotype imputation using unphased genotype data as the references.
Gene - 10 Nov 2015
Li Wenzhi, Xu Wei, Fu Guoxing, Ma Li, Richards Jendai, Rao Weinian, Bythwood Tameka, Guo Shiwen, Song Qing
Abstract excerpt
Enormously growing genomic datasets present a new challenge on missing data imputation, a notoriously resource-demanding task. Haplotype imputation requires ethnicity-matched references. However, to date, haplotype references are not available for the majority of populations in the world. We explored to use existing unphased genotype datasets as references; if it succeeds, it will cover almost all of the...
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