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Article

Genotype Imputation with Millions of Reference Samples.

American journal of human genetics - 7 Jan 2016

Browning Brian L, Browning Sharon R

Abstract excerpt

We present a genotype imputation method that scales to millions of reference samples. The imputation method, based on the Li and Stephens model and implemented in Beagle v.4.1, is parallelized and memory efficient, making it well suited to multi-core computer processors. It achieves fast, accurate, and memory-efficient genotype imputation by restricting the probability model to markers that are genotyped in the...

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Identifiers

PMID: 26748515
DOI: 10.1016/j.ajhg.2015.11.020
PMCID: PMC4716681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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