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Article

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

The Journal of pathology - 1 May 2009

Lavra Luca, Ulivieri Alessandra, Rinaldo Cinzia, Dominici Roberto, Volante Marco, Luciani Emidio, Bartolazzi Armando, Frasca Francesco, Soddu Silvia, Sciacchitano Salvatore

Abstract excerpt

Galectin-3 (Gal-3) is an anti-apoptotic molecule of the beta-galactoside-binding lectin family. Gal-3 is down-regulated by wt-p53 and this repression is required for p53-induced apoptosis. Since poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid carcinomas (ATCs) frequently harbour p53 mutations, we asked whether Gal-3 expression and activity could be influenced by such mutations in these...

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PMID: 19199318
DOI: 10.1002/path.2510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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