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Article

FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status.

International journal of oncology - 1 Jun 2017

Tsuchida Nobuo, Ikeda Masa-Aki, Ιshino Υoshizumu, Grieco Michele, Vecchio Giancarlo

Abstract excerpt

Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced...

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Source

Identifiers

PMID: 28440416
DOI: 10.3892/ijo.2017.3968

Genes

FUCA1
FUT8
FUCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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