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Article

A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(1)-acid glycoprotein.

Journal of pharmaceutical sciences - 1 Nov 2009

Nishi Koji, Ueno Megumi, Murakami Yuka, Fukunaga Naoko, Akuta Teruo, Kadowaki Daisuke, Watanabe Hiroshi, Suenaga Ayaka, Maruyama Toru, Otagiri Masaki

Abstract excerpt

Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid residues that are responsible for the selectivity of drug binding to genetic variants of AGP using site-directed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19198000
DOI: 10.1002/jps.21697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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