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Article

Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein.

Molecular pharmaceutics - 5 Aug 2024

Nakamura Yuka, Watanabe Hiroshi, Nakamura Teruya, Chirifu Mami, Ishiodori Kana, Imafuku Tadashi, Maeda Hitoshi, Kobashigawa Yoshihiro, Morioka Hiroshi, Maruyama Toru

Abstract excerpt

The plasma protein α1-acid glycoprotein (AGP) primarily affects the pharmacokinetics of basic drugs. There are two AGP variants in humans, A and F1*S, exhibiting distinct drug-binding selectivity. Elucidation of the drug-binding selectivity of human AGP variants is essential for drug development and personalized drug therapy. Herein, we aimed to establish the contribution of amino acids 112 and 114 of human AGP...

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Identifiers

PMID: 38949624
DOI: 10.1021/acs.molpharmaceut.4c00428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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