Article
Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D.
PLoS genetics - 1 Feb 2009
Ramagopalan Sreeram V, Maugeri Narelle J, Handunnetthi Lahiru, Lincoln Matthew R, Orton Sarah-Michelle, Dyment David A, Deluca Gabriele C, Herrera Blanca M, Chao Michael J, Sadovnick A Dessa, Ebers George C, Knight Julian C
Abstract excerpt
Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region exerts the single strongest effect on genetic risk. Epidemiological data in MS provide strong evidence that environmental factors act at a population level to influence the unusual geographical distribution of this disease. Growing evidence implicates sunlight or vitamin D as a key environmental factor in aetiology....
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