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Article

Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.

PloS one - 1 Jan 2012

Cocco Eleonora, Meloni Alessandra, Murru Maria Rita, Corongiu Daniela, Tranquilli Stefania, Fadda Elisabetta, Murru Raffaele, Schirru Lucia, Secci Maria Antonietta, Costa Gianna, Asunis Isadora, Cuccu Stefania, Fenu Giuseppe, Lorefice Lorena, Carboni Nicola, Mura Gioia, Rosatelli Maria Cristina, Marrosu Maria Giovanna

Abstract excerpt

Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion. The Italian island of Sardinia exhibits a very high frequency of MS and high solar radiation exposure. We test the...

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PMID: 22848563
DOI: 10.1371/journal.pone.0041678
PMCID: PMC3404969

Genes

VDR

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