Creation of interferon-alpha8 mutants with amino acid substitutions against interferon-alpha receptor-2 binding sites using phage display system and evaluation of their biologic properties.

doi:10.1089/jir.2008.0038

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Article

Creation of interferon-alpha8 mutants with amino acid substitutions against interferon-alpha receptor-2 binding sites using phage display system and evaluation of their biologic properties.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2009

Yamamoto Kouzo, Taniai Madoka, Torigoe Kakuji, Yamamoto Shigeto, Arai Norie, Suemoto Yasuo, Yoshida Kenshi, Okura Takanori, Mori Tetsuya, Fujioka Noboru, Tanimoto Tadao, Miyata Manabu, Ariyasu Harumi, Ushio Chie, Fujii Mitsukiyo, Ariyasu Toshio, Ikeda Masao, Ohta Tsunetaka, Kurimoto Masashi, Fukuda Shigeharu

Abstract excerpt

In this study, we describe the creation of three interferon-alpha (IFN-alpha)8 mutants with markedly higher antiviral and antiproliferative activities in comparison with those of the wild-type (wt)IFN-alpha8, wtIFN-alpha2, and IFN-con1 using a phage display system. Sequence analysis showed that three out of the six hot-spot amino acid residues of wtIFN-alpha8 known to be important for the interaction with the...

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PMID: 19196068
DOI: 10.1089/jir.2008.0038

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