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Article

[Mutation of LoopAB in HuIFN 1c/86D and enhancement of antiviral activity].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Jun 2002

Hu Rong, Ma Xuejun, Wei Kaikun, Wang Hong, Qian Zhenchao, Xue Shuixing, Duan Zhaojun, Hou Yunde

Abstract excerpt

BACKGROUND: Based on the earlier mapping of the epitope recognized by neutralizing antibody, the authors directly replaced binding domain of IFN in AB-loop for enhancement of biological activity. METHODS: Two unique restriction sites (EcoR? and BsE?) were created into region flanking LoopAB. Casette mutagesis, restriction enzyme digestion, DNA sequencing, antiviral activity assay and antiproliferative activity...

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PMID: 12196823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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