Article
Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Feb 2009
Diekmann Heike, Anichtchik Oleg, Fleming Angeleen, Futter Marie, Goldsmith Paul, Roach Alan, Rubinsztein David C
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant, neurodegenerative condition caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein huntingtin. Genetic and transgenic studies suggest that the mutation causes disease predominantly via gain-of-function mechanisms. However, loss of normal huntingtin function resulting from the polyglutamine...
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