Article
Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018
Siebzehnrübl Florian A, Raber Kerstin A, Urbach Yvonne K, Schulze-Krebs Anja, Canneva Fabio, Moceri Sandra, Habermeyer Johanna, Achoui Dalila, Gupta Bhavana, Steindler Dennis A, Stephan Michael, Nguyen Huu Phuc, Bonin Michael, Riess Olaf, Bauer Andreas, Aigner Ludwig, Couillard-Despres Sebastien, Paucar Martin Arce, Svenningsson Per, Osmand Alexander, Andreew Alexander, Zabel Claus, Weiss Andreas, Kuhn Rainer, Moussaoui Saliha, Blockx Ines, Van der Linden Annemie, Cheong Rachel Y, Roybon Laurent, Petersén Åsa, von Hörsten Stephan
Abstract excerpt
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy remains...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.