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Article

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands.

The Journal of biological chemistry - 3 Apr 2009

Walton Kelly L, Makanji Yogeshwar, Wilce Matthew C, Chan Karen L, Robertson David M, Harrison Craig A

Abstract excerpt

The assembly and secretion of transforming growth factor beta superfamily ligands is dependent upon non-covalent interactions between their pro- and mature domains. Despite the importance of this interaction, little is known regarding the underlying regulatory mechanisms. In this study, the binding interface between the pro- and mature domains of the inhibin alpha-subunit was characterized using in vitro...

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Identifiers

PMID: 19193648
DOI: 10.1074/jbc.M808763200
PMCID: PMC2666583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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