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Article

SEA domain proteolysis determines the functional composition of dystroglycan.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2008

Akhavan Armin, Crivelli Silvia N, Singh Manisha, Lingappa Vishwanath R, Muschler John L

Abstract excerpt

Post-translational modifications of the extracellular matrix receptor dystroglycan (DG) determine its functional state, and defects in these modifications are linked to muscular dystrophies and cancers. A prominent feature of DG biosynthesis is a precursor cleavage that segregates the ligand-binding and transmembrane domains into the noncovalently attached alpha- and beta-subunits. We investigate here the...

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Source

Identifiers

PMID: 17905726
DOI: 10.1096/fj.07-8354com

Genes

SEA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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