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Article

A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.

Science signaling - 3 Apr 2012

Akiyama Takuya, Marqués Guillermo, Wharton Kristi A

Abstract excerpt

Dimers of conventional transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) ligands are composed of two 100- to 140-amino acid peptides that are produced through the proteolytic processing of a proprotein precursor by proconvertases, such as furin. We report the identification of an evolutionarily conserved furin processing site in the amino terminus (NS) of the Glass bottom boat (Gbb; the...

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Anti-Mullerian Hormone
Bone Morphogenetic Protein 15
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins
Cleft Lip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mullerian Ducts

Proprotein Convertases

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Identifiers

PMID: 22472650
DOI: 10.1126/scisignal.2002549
PMCID: PMC3699424

Genes

BMP15
BMP4
BMP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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