Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

You're going to need a bigger (glass bottom) boat.

Science signaling - 3 Apr 2012

Peterson Aidan J, O'Connor Michael B

Abstract excerpt

Signaling molecules of the transforming growth factor (TGF)-β family are generated from proprotein precursors containing prodomain sequences that are typically removed to allow signaling by the mature ligands. A form of a TGF-β family ligand that remains covalently attached to its prodomain but retains signaling activity has been identified. Glass bottom boat (Gbb), a Drosophila homolog of the bone morphogenetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Isoforms

Share to Protein Precursors

Share to Protein Processing, Post-Translational

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 22472647
DOI: 10.1126/scisignal.2002998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

You're going to need a bigger (glass bottom) boat.PMID 22472647Read ↗

A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.Semantic proximity Read ↗

Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster.Semantic proximity Read ↗

Latent TGF-β structure and activation.Semantic proximity Read ↗

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice.Semantic proximity Read ↗

The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.Semantic proximity Read ↗

Prodomain-growth factor swapping in the structure of pro-TGF-β1.Semantic proximity Read ↗

GDF11 and aging biology - controversies resolved and pendingSemantic proximity Read ↗

Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development.Semantic proximity Read ↗

Structure of bone morphogenetic protein 9 procomplexSemantic proximity Read ↗

The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivoSemantic proximity Read ↗

Molecular characterization of latent GDF8 reveals mechanisms of activation.Semantic proximity Read ↗

Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.