Article
Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.
The Journal of biological chemistry - 3 Apr 2009
Webber Jason, Meran Soma, Steadman Robert, Phillips Aled
Abstract excerpt
The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the context of organ fibrosis, however, persistence of these myofibroblasts is associated with progressive disease. This study examines mechanisms controlling the maintenance of the myofibroblast phenoty...
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