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Article

Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype.

The Journal of biological chemistry - 1 May 2015

Midgley Adam C, Duggal Lucy, Jenkins Robert, Hascall Vincent, Steadman Robert, Phillips Aled O, Meran Soma

Abstract excerpt

Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies have demonstrated that HA can both mediate and modulate BMP7 responses. In this study, we investigated whether BMP7 can modulate HA in a manner that leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25716319
DOI: 10.1074/jbc.M114.625939
PMCID: PMC4416830

Genes

BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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