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Article

Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.

The Journal of biological chemistry - 23 Jul 2010

Twarock Sören, Tammi Markku I, Savani Rashmin C, Fischer Jens W

Abstract excerpt

Hyaluronan (HA) is a polysaccharide component in the parenchyma and stroma of human esophageal squamous cell carcinoma (ESCC). Clinically, esophageal cancer represents a highly aggressive tumor type with poor prognosis resulting in a 5-year survival rate of 5%. The aim of the present study was the detailed analysis of the role of HA synthesis for ESCC phenotype in vitro using the ESCC cell line OSC1. In OSC1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 20463012
DOI: 10.1074/jbc.M109.093146
PMCID: PMC2906320

Genes

HAS2
HAS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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