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Article

Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.

The American journal of pathology - 1 Mar 2010

Simpson Russell M L, Wells Alan, Thomas David, Stephens Philip, Steadman Robert, Phillips Aled

Abstract excerpt

Fibroblast differentiation into myofibroblasts is a key event during normal wound repair. We have previously demonstrated an age-related defect in this process associated with impaired synthesis of hyaluronan (HA) synthase (HAS) 2 but failed to prescribe its role in a mechanistic sense. Here we demonstrate that in addition to HAS2, there is loss of EGF receptor (EGF-R) in aged cells, and both are required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20093489
DOI: 10.2353/ajpath.2010.090802
PMCID: PMC2832144

Genes

EGF
HAS2

Provenance

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