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Article

Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.

The American journal of pathology - 1 Nov 2009

Simpson Russell M L, Meran Soma, Thomas David, Stephens Philip, Bowen Timothy, Steadman Robert, Phillips Aled

Abstract excerpt

We have previously demonstrated that transforming growth factor-beta1 (TGF-beta1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation of a hyaluronan (HA) pericellular coat. The current study demonstrates failure of fibroblast-myofibroblast differentiation associated with in vitro aging. This is associated with attenuation of numerous TGF-beta1-dependent responses, including HA...

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Source

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Identifiers

PMID: 19808648
DOI: 10.2353/ajpath.2009.090045
PMCID: PMC2774056

Genes

HAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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