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Article

Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover.

The Journal of biological chemistry - 1 Oct 2004

Jenkins Robert H, Thomas Gareth J, Williams John D, Steadman Robert

Abstract excerpt

During the initiation and progression of fibrosis there is extensive differentiation of cells to a myofibroblastic phenotype. Because the synthesis of hyaluronan (HA) was recently linked to oncogenic epithelial-mesenchymal transformation, the present study investigated whether increased HA synthesis was also associated with myofibroblastic differentiation. HA synthesis and size were measured by incorporation of...

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Identifiers

PMID: 15271981
DOI: 10.1074/jbc.M401678200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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