Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover.

The Journal of biological chemistry - 1 Oct 2004

Jenkins Robert H, Thomas Gareth J, Williams John D, Steadman Robert

Abstract excerpt

During the initiation and progression of fibrosis there is extensive differentiation of cells to a myofibroblastic phenotype. Because the synthesis of hyaluronan (HA) was recently linked to oncogenic epithelial-mesenchymal transformation, the present study investigated whether increased HA synthe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules
Share to Fibrosis
Share to Glucuronosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to Hyaluronic Acid

Share to Hyaluronoglucosaminidase

Share to Muscle Cells

Share to Transferases

Source

Identifiers

PMID: 15271981
DOI: 10.1074/jbc.M401678200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15271981-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover.PMID 15271981Read ↗

Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen MatricesSemantic proximity Read ↗

Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skinSemantic proximity Read ↗

Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skinSemantic proximity Read ↗

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.Semantic proximity Read ↗

Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.Semantic proximity Read ↗

Involvement of hyaluronan in regulation of fibroblast phenotype.Semantic proximity Read ↗

Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype.Semantic proximity Read ↗

Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation.Semantic proximity Read ↗

Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skinSemantic proximity Read ↗

Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction.Semantic proximity Read ↗

Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.Semantic proximity Read ↗

Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.