Article
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Human molecular genetics - 15 Apr 2009
Chiò Adriano, Schymick Jennifer C, Restagno Gabriella, Scholz Sonja W, Lombardo Federica, Lai Shiao-Lin, Mora Gabriele, Fung Hon-Chung, Britton Angela, Arepalli Sampath, Gibbs J Raphael, Nalls Michael, Berger Stephen, Kwee Lydia Coulter, Oddone Eugene Z, Ding Jinhui, Crews Cynthia, Rafferty Ian, Washecka Nicole, Hernandez Dena, Ferrucci Luigi, Bandinelli Stefania, Guralnik Jack, Macciardi Fabio, Torri Federica, Lupoli Sara, Chanock Stephen J, Thomas Gilles, Hunter David J, Gieger Christian, Wichmann H Erich, Calvo Andrea, Mutani Roberto, Battistini Stefania, Giannini Fabio, Caponnetto Claudia, Mancardi Giovanni Luigi, La Bella Vincenzo, Valentino Francesca, Monsurrò Maria Rosaria, Tedeschi Gioacchino, Marinou Kalliopi, Sabatelli Mario, Conte Amelia, Mandrioli Jessica, Sola Patrizia, Salvi Fabrizio, Bartolomei Ilaria, Siciliano Gabriele, Carlesi Cecilia, Orrell Richard W, Talbot Kevin, Simmons Zachary, Connor James, Pioro Erik P, Dunkley Travis, Stephan Dietrich A, Kasperaviciute Dalia, Fisher Elizabeth M, Jabonka Sibylle, Sendtner Michael, Beck Marcus, Bruijn Lucie, Rothstein Jeffrey, Schmidt Silke, Singleton Andrew, Hardy John, Traynor Bryan J
Abstract excerpt
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the...
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