Article
A high-density genome-wide association screen of sporadic ALS in US veterans.
PloS one - 1 Jan 2012
Kwee Lydia Coulter, Liu Yutao, Haynes Carol, Gibson Jason R, Stone Annjanette, Schichman Steven A, Kamel Freya, Nelson Lorene M, Topol Barbara, Van den Eeden Stephen K, Tanner Caroline M, Cudkowicz Merit E, Grasso Daniela L, Lawson Robert, Muralidhar Sumitra, Oddone Eugene Z, Schmidt Silke, Hauser Michael A
Abstract excerpt
Following reports of an increased incidence of amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) of ALS outcome and survival time in a sample of U.S. veterans. We tested ∼1.3 million single nucleotide polymorphisms (SNPs) for association with ALS outcome in 442 incident Caucasian veteran cases diagnosed with definite or probable ALS and 348...
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