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Article

Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

Neurobiology of aging - 1 Jul 2014

Xie Tong, Deng Libin, Mei Puming, Zhou Yiyi, Wang Bo, Zhang Jie, Lin Jiari, Wei Yi, Zhang Xiong, Xu Renshi

Abstract excerpt

Sporadic amyotrophic lateral sclerosis (sALS) is a severe neurodegenerative disease that causes progressive motor neuron death. Although the etiology of sALS remains unknown, genetic variants are thought to predispose individuals to the disease. Several recent genome-wide association studies have identified a number of loci that increase sALS susceptibility, but these only explain a small proportion of the...

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PMID: 24529757
DOI: 10.1016/j.neurobiolaging.2014.01.014

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ATXN1
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