Article
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
Nature genetics - 1 Jun 2013
Deng Min, Wei Ling, Zuo Xianbo, Tian Yanghua, Xie Fei, Hu Panpan, Zhu Chunyan, Yu Fengqiong, Meng Yu, Wang Honghao, Zhang Fangfang, Ma Huijuan, Ye Rong, Cheng Huaidong, Du Jing, Dong Wenwen, Zhou Shanshan, Wang Changqing, Wang Yu, Wang Jingye, Chen Xianwen, Sun Zhongwu, Zhou Nong, Jiang Yubao, Liu Xiuxiu, Li Xiaogang, Zhang Nan, Liu Na, Guan Yingjun, Han Yongsheng, Han Yongzhu, Lv Xinyi, Fu Yu, Yu Hui, Xi Chunhua, Xie Dandan, Zhao Qiyuan, Xie Peng, Wang Xin, Zhang Zhijun, Shen Lu, Cui Yong, Yin Xianyong, Cheng Hui, Liang Bo, Zheng Xiaodong, Lee Tatia M C, Chen Gang, Zhou Fusheng, Veldink Jan H, Robberecht Wim, Landers John E, Andersen Peter M, Al-Chalabi Ammar, Shaw Chris, Liu Chunfeng, Tang Beisha, Xiao Shangxi, Robertson Janice, Zhang Fengyu, van den Berg Leonard H, Sun Liangdan, Liu Jianjun, Yang Sen, Ju Xiaodong, Wang Kai, Zhang Xuejun
Abstract excerpt
To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered...
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