Article
C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2009
Yang Dong-Hua, Smith Elizabeth R, Cai Kathy Qi, Xu Xiang-Xi
Abstract excerpt
Disabled-2 (Dab2) is expressed in primitive endoderm cells as they are differentiating from the inner cell mass and dab2 deficiency in mice results in lethality at E5.5-E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c-Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5.5 dab2 (-/-):c-fos (-/-) embryos, indicating...
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