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Article

Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors.

Cells - 21 Jun 2022

Dias Carvalho Patrícia, Martins Flávia, Carvalho Joana, Oliveira Maria José, Velho Sérgia

Abstract excerpt

Understanding how mutant KRAS signaling is modulated by exogenous stimuli is of utmost importance to elucidate resistance mechanisms underlying pathway inhibition failure, and to uncover novel therapeutic targets for mutant KRAS patients. Hence, aiming at perceiving KRAS-autonomous versus -non autonomous mechanisms, we studied the response of two mutant KRAS colorectal cancer cell lines (HCT116 and LS174T) upon...

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Cell Line, Tumor
Colorectal Neoplasms
Mutation
Proteome
Proteomics
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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Identifiers

PMID: 35805073
DOI: 10.3390/cells11131988
PMCID: PMC9265670

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