Article
The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients.
Endocrine - 1 Jul 2017
Young Cho Yoon, Jeong Kim Hye, Won Jang Hye, Hyuk Kim Tae, Ki Chang-Seok, Wook Kim Sun, Hoon Chung Jae
Abstract excerpt
PURPOSE: Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relationship between commonly inherited variations in type 2 iodothyronine deiodinase and impaired...
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