Article
Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma.
Experimental & molecular medicine - 1 May 2018
Choi Gil-Soon, Trinh Hoang Kim Tu, Yang Eun-Mi, Ye Young-Min, Shin Yoo Seob, Kim Seung-Hyun, Park Hae-Sim
Abstract excerpt
Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients...
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