Article
Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2005
Matheson Joanna M, Johnson Victor J, Luster Michael I
Abstract excerpt
Isocyanate-induced asthma, which is the most common type of occupational asthma, has been difficult to diagnose and control, in part, because the biological mechanisms responsible for the disease and the determinants of exposure are not fully defined. To help address these issues, we recently established a murine model of toluene diisocyanate (TDI) asthma using inhalation exposure paradigms consistent with...
Topics
- Allergens
- Animals
- Asthma
- Bronchial Hyperreactivity
- Bronchoalveolar Lavage Fluid
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cytokines
- Enzyme-Linked Immunosorbent Assay
- Eosinophils
- Immunoglobulin E
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Occupational Diseases
- Peroxidases
- Phenotype