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Article

Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals.

Molecular carcinogenesis - 1 Aug 2009

Xu Haibo, McCann Mella, Zhang Zhiyu, Posner Gary H, Bingham Victoria, El-Tanani Mohamed, Campbell Frederick C

Abstract excerpt

Vitamin D receptor (VDR) can modulate functionally antagonistic growth regulatory pathways, involving beta-catenin/E-cadherin on one hand and osteopontin (OPN) on the other. This study investigates effects of VDR ligand treatment on the balance of these discordant signals and on associated cell behavior. Treatment of Rama 37 or SW480 cells by 1alpha,25-(OH)(2) D(3) or analogs suppressed beta-catenin/Lef-1/Tcf...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19184984
DOI: 10.1002/mc.20520

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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