Article
Vitamin D regulates the phenotype of human breast cancer cells.
Differentiation; research in biological diversity - 1 Mar 2007
Pendás-Franco Natalia, González-Sancho José Manuel, Suárez Yajaira, Aguilera Oscar, Steinmeyer Andreas, Gamallo Carlos, Berciano María T, Lafarga Miguel, Muñoz Alberto
Abstract excerpt
1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the most active vitamin D metabolite, regulates proliferation, survival, and differentiation in many cell types. 1,25(OH)(2)D(3) and several less calcemic analogs are in clinical trials against various neoplasias. We studied the effects of 1,25(OH)(2)D(3) on a panel of human breast cancer cells, which show similar vitamin D receptor (VDR) content but variable...
Topics
- Animals
- Biomarkers, Tumor
- Breast Neoplasms
- Cadherins
- Calcitriol
- Cell Movement
- Cell Proliferation
- Cell Size
- Female
- Focal Adhesions
- Humans
- Immunohistochemistry
- Mice
- Phenotype
- Tumor Cells, Cultured