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Article

The Role of LEF/TCF Factors in Neoplastic Transformation

1 Feb 2008

Abstract excerpt

The T cell factor 4 (Tcf-4) interacts with beta-catenin in the Wnt signalling pathway and coactivates downstream target genes in diverse systems including the breast. This activity is important during normal development but its deregulation plays a pivotal role in cancer progression. In a rat model for breast cancer it has been shown that metastasis-inducing DNA (Met-DNA) sequesters the endogenous inhibitory...

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PMID: 18289012
DOI: 10.2174/156652408783565559

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