A Dominant Negative Cadherin Inhibits Osteoblast Differentiation

doi:10.1359/jbmr.2000.15.12.2362

Article

A Dominant Negative Cadherin Inhibits Osteoblast Differentiation

1 Dec 2000

Abstract excerpt

We have previously indicated that human osteoblasts express a repertoire of cadherins and that perturbation of cadherin-mediated cell-cell interaction reduces bone morphogenetic protein 2 (BMP-2) stimulation of alkaline phosphatase activity. To test whether inhibition of cadherin function interferes with osteoblast function, we expressed a truncated N-cadherin mutant (NCaddeltaC) with dominant negative action in...

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