Article
The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm.
Oncotarget - 18 Apr 2017
Trivedi Trupti, Zheng Yu, Fournier Pierrick G J, Murthy Sreemala, John Sutha, Schillo Suzanne, Dunstan Colin R, Mohammad Khalid S, Zhou Hong, Seibel Markus J, Guise Theresa A
Abstract excerpt
Vitamin D has pleiotropic effects on multiple tissues, including malignant tumors. Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Here, we demonstrate that the VDR can also function in the absence of its ligand to control behaviour of human breast cancer cells both outside and within the bone microenvironment. Stable shRNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.