Article
Common variants of the glial cell-derived neurotrophic factor gene do not influence kidney size of the healthy newborn.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2009
Zhang Zhao, Quinlan Jackie, Grote David, Lemire Mathieu, Hudson Thomas, Benjamin Alice, Roy Anne, Pascuet Elena, Goodyer Meigan, Raju Chandhana, Houghton Fiona, Bouchard Maxime, Goodyer Paul
Abstract excerpt
Glial cell-derived neurotrophic factor (GDNF) plays an important role in renal development, serving as a trophic factor for outgrowth of the ureteric bud and its continued arborisation. Our previous studies have shown that common variants of the human paired-box 2 (PAX2) gene (a transcriptional activator of GDNF) and rearranged during transfection (RET) gene (encoding the cognate receptor for GDNF) are associated...
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